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Home > Publications > Integrated Molecular Characterization of Uterine Carcinosarcoma, 2017

Integrated Molecular Characterization of Uterine Carcinosarcoma

Cancer Cell, Volume 31, Issue 3, p411–423, 13 March 2017

[doi:10.1016/j.ccell.2017.02.010]

Abstract

We performed genomic, epigenomic, transcriptomic and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7 and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigenetic alterations at microRNA promoters. The range of EMT scores in UCS was the largest amongst all tumor types studied via The Cancer Genome Atlas. UCSs shared proteomic features with gynecologic carcinomas and sarcomas with intermediate EMT features. Multiple somatic mutations and copy number alterations in genes that are therapeutic targets were identified.

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The data are supported by different organizations. All data marked by [DCC] are DCC-validated archives. All data marked by [Supplementary] were created by the manuscript authors and you should contact the corresponding author for support.

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Clinical

Microsatellite Instability

Mutations

Reverse Phase Protein Array (RPPA) Expression

RNA Expression from IlluminaHiseq RNASeq

SNP and Copy Number variation from Affymetrix SNP6

miRNA from Illumina HiSeq 2000

Methylation from Illumina Infinium Human Methylation450

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